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KMID : 0377619730250040401
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Korean Jungang Medical Journal
1973 Volume.25 No. 4 p.401 ~ p.408
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Effectiveness of Pyrantel Pamoate (Combantrin) in the Masstreatment of Aseariasis with Low Dosage Schedule
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ßïÜ°àÙ/Seo, Byong-Seol
ì°âíû¦/ðáã°æï/Ë©ãáç´/åÄéÌà´/üÜÏÈìé/ÚÓïÒФ/Lee, Soon-Hyung/Cho, Seung-Yull/Kang, Shin-Yong/Ryang, Yong-Suk/Whang, Koo-Il/Lim, Jung-Kyoo
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Abstract
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The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea.
A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of¢¥ pyrantel pamoate.
A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen.
For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll¢¥s Egg Counting Technique).
The results obtained were;
1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6).
2. The reduction rates were also obtained just as the same order of the above results.
3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1).
4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5).
5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics.
From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.
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